Insilico Interaction Of Selected Terpenoids Against Oral Biofilm (Streptococcus Mutans) Drug Targets.
Journal of Contemporary Issues in Business and Government,
2021, Volume 27, Issue 2, Pages 4357-4359
10.47750/cibg.2021.27.02.462
Abstract
Aim: The aim is to analyse the In Silico interaction of selected terpenoids against streptococcus mutans drug targets.Materials And Methods: • Retrieval of protein using ligand structure.
• Molecular docking using iGemdock.
Results: From this study it is evident that docking is significant in Neptalactone. It has the highest fitness (-48.4), lowest VDW (-32.02), and H bond equal to standard inhibitor (-16.33).
Conclusion:The compound Neptalactone with the highest docking score is most efficient in blocking biofilm formation when compared to other compounds.
Keywords:
Main Subjects:
- Soheila Abachi et al, Molecular Mechanisms of Inhibition of Streptococcus Species by Phytochemicals, doi:10.3390, 2016.
- Shi, E. Flesh-Eating Bacteria: Various Strains and Virulence. Personal communication, University of California: Davis, CA, USA, 2009.
- Hayes, C.S.; Williamson, H., Jr. Management of group a beta-hemolytic streptococcal pharyngitis. Am. Fam. Phys. 2001, 63, 1557–1565.
- Baron, S.; Davis, C.P. Normal flora. In Medical Microbiology, 4th ed.; Baron, S., Ed.; University of Texas Medical Branch: Galveston, TX, USA, 1996.
- Marta Ribeiro et al, Cytotoxicity and antimicrobial action of selected phytochemicals against planktonic and sessile Streptococcus mutans, DOI 10.7717, 2018.
- Mitchell, T.J. The pathogenesis of streptococcal infections: From tooth decay to meningitis. Nat. Rev. Microbiol. 2003, 1, 219–230.
- Nobbs, A.H.; Lamont, R.J.; Jenkinson, H.F. Streptococcus adherence and colonization. Microbiol. Mol. Biol. Rev. 2009, 73, 407–450.
- Matsui, R.; Cvitkovitch, D. Acid tolerance mechanisms utilized by Streptococcus mutans. Future Microbiol. 2010, 5, 403–417.
- Robert Matsui, Acid tolerance mechanisms utilized by Streptococcus mutans, 2010, 5(3), 403-417.
- Chan YH, Fan MM, Fok CM, et al. (2012). Antibiotics nonadherence and knowledge in a community with the world’s leading prevalence of antibiotics resistance: Implications for public health intervention. Am J Infect Control 40:113–17
- Song JM, Seong BK. (2007). Tea catechins as a potential alternative anti-infectious agent. Expert Rev Anti Infect Ther 5:497–506
- Aderem A, Adkins JN, Ansong C, et al. (2011). A systems biology approach to infectious disease research: Innovating the pathogen-host research paradigm. MBio 2:e00325–10 13. Hsu, Kai-Cheng, Yen-Fu Chen, Shen-Rong Lin, and Jinn-Moon Yang. 2011. “IGEMDOCK: A Graphical Environment of Enhancing GEMDOCK Using Pharmacological Interactions and Post-Screening Analysis.” BMC Bioinformatics 12(Suppl 1):S33.
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