FSH status in normal and obese individuals
Journal of Contemporary Issues in Business and Government,
2021, Volume 27, Issue 2, Pages 3924-3927
AbstractObesity is one of the major and common health problems in all developed and developing countries leading to infertility. It also acts as an important modifier of reproductive hormones. Follicle-stimulating hormone (FSH), a pituitary-derived glycoprotein hormone, is associated in reproductive activities such as formation of gonadal and germ cells and the development of sex hormones. The goal of this study was to assess the FSH level in normal and obese individuals. 60 subjects were chosen from those attending the outpatient department of a private hospital and divided into two groups (n=30). Group1 served as control having healthy individuals, Group 2 served as study group with obese individuals. 5 ml of venous blood was collected from the participants after informed consent and was centrifuged at 2500 rpm for 10 minutes. The serum was separated and analysed for serum FSH by standard enzyme linked immunosorbent assay technology (ELISA) using Robonik Elisa reader. The mean BMI levels between the groups were 21.98±2.59 and 34.42±3.82 respectively. The mean FSH levels between the groups were 10.43±4.43 and 5.59±2.53respectively. These results were analysed by student t-test and showed significant difference between these two groups (p <0.0001). Obese individuals had low FSH levels, when compared to the normal healthy individuals. The findings clearly indicate that there is an association between obesity and hormone changes in individuals.
- Asayama K, Hayashibe H, Dobashi K, Uchida N, Nakane T, Kodera K, Shirahata A, Taniyama M, 2003. Decrease in serum adiponectin level due to obesity and visceral fat accumulation in children. Obes. Res. 11:1072–1079.
- Clark AM, 1996. Weight loss in obese infertile women results in improvement in reproductive outcome for all forms of fertility treatment, Fertility and foods, 13(6) ;1502–1505.
- De Pergola G, Maldera S,Tartagni M, Pannacciulli N, Loverro G, R Giorgino R(2006). Inhibitory Effect of Obesity on Gonadotropin,Estradiol, and Inhibin B Levels in Fertile Women, Obesity, 14(11): 1954–1960.
- Freeman EW.2010. Obesity and Reproductive Hormone Levels in the Transition to Menopause, Menopause , New York . 17(4): 718–726.
- Freeman EW, Sammel MD, Gracia ,CR. Follicular phase hormone levels and menstrual bleeding status in the approach to menopause. Fertil Steril .2005;83:383–392.
- Grenman,S.,Ronnemaa,T.,Irjala,K.,Kaihola,HL.,Gronroos,M.Sexsteroid, gonadotropin, cortisol, and prolactin levels in healthy, massively obese women: correlation with abdominal fat cell size and effect of weight reduction. J Clin Endocrinol Metab. 1986;63:1257–61.
- Lago F, Gomez R, Gomez-Reino JJ, Dieguez C, Gualillo O. 2009. Adipokines as novel modulators of lipid metabolism. Trends Biochem. Sci. 34:500–510
- Loh S, Wang JX. 2002. The influence of body mass index, basal FSH and age on the response to gonadotrophin stimulation in non-polycystic ovarian syndrome patients. Human reproduction. 17(5): 1207–1211.
- Norman RJ, Noakes M, Wu R, Davies MJ, Moran L, Wang JX 2004. Improving reproductive performance in overweight/obese women with effective weight management. Hum Reprod Update.10:267–80.
- Norman RJ 2004. Improving reproductive performance in overweight/obese women with effective weight management. Human Reproduction Update .10(3) :267-280.
- Norman RJ, Masters SC, Hague W, Beng C, Pannall P, Wang JX. 1995. Metabolic approaches to the subclassification of polycystic ovary syndrome. Fertil Steril 63:329-335.
- Parihar M 2003. Obesity and infertility. Reviews in Gynecological Practice. 3: 120-126.
- Pratt LA, Brody DJ 2014. Depression and obesity in the U.S. adult household population, NCHS Data BrieF.167:1–8.
- RichEdwards JW, Goldman MB, Willett WC, Hunter DJ, Stampfer, MJ,
- Colditz GA , Manson JE (1994). Adolescent body mass index and infertility caused by ovulatory disorder. American Journal of Obstetrics and Gynecology , 17(1): 171–177.
- Roest J, van Heusden AM, Mous H, Zeilmaker, GH Verhoe A (1996). The ovarian response as a predictor for successful in vitro fertilization treatment at the age of 40 years. Fertil. Steril. 66, 969–973.
- Sharpe RM and Franks S. 2002. Environment, lifestyle and infertility inter-generational issue. Nature Cell Biol. 4:33-40.
- Sheik R, 2015.Awareness of Obesity as a Risk Factor for Polycystic Ovary Syndrome, J. Pharm. Sci. & Res. 7(7): 471-473.
- Sheethalan MSR, Shankari, 2016. Physical fitness and dietary habit levels among different periodontal health conditions individuals - a cross sectional questionnaire study, International Journal of Pharmaceuticals and Research, 7(11):14401-14404.
- Sattar N, Wannamethee G, Sarwar N, Chernova J, Lawlor DA, Kelly, Wallace AM, Danesh J, Whincup PH. 2009. Leptin and coronary heart disease: prospective study and systematic review. J. Am. Coll. Cardiol. 53:167–175.
- Trujillo ME, Scherer PE 2006. Adipose tissue-derived factors: impact on health and disease. Endocr. Rev. 27:762–778
- Tamer Erel C, Senturk LM. 2009. The impact of body mass index on assisted reproduction. Current Opinion in Obstetrics and Gynecology; 21: 228–235.
- Xin-Mei Liu.2017. FSH regulates fat accumulation and redistribution in aging through the Gai/Ca2+/CREB pathway.Aging Cell.14;409–420.
- Yang WS, Lee WJ, Funahashi T, Tanaka S, Matsuzawa Y, Chao CL, Chen CL, Tai, TY, Chuang LM. 2001. Weight reduction increases plasma levels of an adipose-derived anti-inflammatory protein, adiponectin. J. Clin. Endocrinol. Metab.86:3815–3819.
- Zhou, 2013.Serum FSH level associated with her-2 and ki67 expression. Oncology letter. 6(4): 1128-1132
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